Proton Transfer Reaction Mass Spectrometry Principles And Applications Pdf

proton transfer reaction mass spectrometry principles and applications pdf

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Proton-transfer-reaction mass spectrometry PTR-MS is an analytical chemistry technique that uses gas phase hydronium reagent ions which are produced in an ion source. Commercially available PTR-MS instruments have a response time of about ms and reach a detection limit in the single digit pptv or even ppqv region.

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The sensitivity of PTR-ToF-MS also depends on the ability to effectively focus and transmit ions from the relatively high-pressure drift tube DT to the low-pressure mass analyzer. IF consists of a series of electrodes with gradually decreasing orifice diameters. Radio frequency RF voltage and direct current DC electric field are then applied to the electrodes to get the ions focused. We investigated the effect of the RF voltage and DC field on the sensitivity of a pattern of VOCs including hydrocarbons, alcohols, aldehydes, ketones, and aromatic compounds. In a proof-of-concept study, the instrument operating both as normal DT DC-mode and at optimal IF conditions RF-mode was applied for the breath analysis of 21 healthy human subjects.

Proton Transfer Reaction Mass Spectrometry PTR-MS is a rapidly growing analytical technique for detecting and identifying very small quantities of chemical compounds in air. It has seen widespread use in atmospheric monitoring and food science and shows increasing promise in applications such as industrial process monitoring, medical science and in crime and security scenarios. Written by leading researchers, this is the first book devoted to PTR-MS and it provides a comprehensive account of the basic principles, the experimental technique and various applications, thus making this book essential reading for researchers, technicians, postgraduate students and professionals in industry. The book contains nine chapters and is divided into two parts. The first part describes the underlying principles of the PTR-MS technique, including the relevant ion-molecule chemistry thermodynamics and reaction kinetics a discussion of ion sources, drift tubes and mass spectrometers practical aspects of PTR-MS, including calibration. The second part of the book turns its attention to some of the many applications of PTR-MS, demonstrating the scope and benefits, as well as the limitations, of the technique. The chapters that make up the second part of the book build upon the material presented in the first part and are essentially self-contained reviews focusing on the following topics: environmental science food science medicine homeland security, and applications of PTR-MS in liquid analysis.

Proton Transfer Reaction Mass Spectrometry: Principles and Applications

Proton transfer reaction- mass spectrometry PTR-MS is a new and emerging technique for the measurement and monitoring of volatile organic compounds VOCs at low concentrations in gaseous samples in more-or-less real time. Utilising chemical ionisation , it combines the desirable attributes of high sensitivity and short integration times with good precision and accuracy. Recently it has been exploited in applications related to atmospheric science. Here, the principles of operation of the PTR-MS are described, its advantages and disadvantages discussed, its inherent uncertainties highlighted, some of its uses in atmospheric sciences reviewed, and some suggestions made on its future application to atmospheric chemistry. If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center.

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Ellis and C. Ellis , C. Mayhew Published Chemistry. Description: Proton transfer reaction mass spectrometry PTR—MS is a specialist technique for detecting and identifying very small quantities amounts of organic gases in air.

Soft chemical ionization mass spectrometric techniques, such as proton transfer reaction mass spectrometry PTR-MS , are often used in breath analysis, being particularly powerful for real-time measurements. To ascertain the type and concentration of volatiles in exhaled breath clearly assignable product ions resulting from these volatiles need to be determined. This is difficult for compounds where isomers are common, and one important class of breath volatiles where this occurs are ketones. Of particular interest is to determine if ketone isomers can be distinguished without the need for pre-separation by manipulating the ion chemistry through changes in the reduced electric field. An additional issue for breath analysis is that the product ion distributions for these breath volatiles are usually determined from direct PTR-MS measurements of the compounds under the normal operating conditions of the instruments. Generally, no account is made for the effects on the ion-molecule reactions by the introduction of humid air samples or increased CO 2 concentrations into the drift tubes of these analytical devices resulting from breath. Therefore, another motivation of this study is to determine the effects, if any, on the product ion distributions under the humid conditions associated with breath sampling.

Proton Transfer Reaction Mass Spectrometry Principles and Applications

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Proton-transfer-reaction mass spectrometry

The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.

Proton-transfer-reaction mass spectrometry

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Introduction

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